Peripheral and lung resident memory T cell responses against SARS-CoV-2

Abstract Resident memory T cells (T RM ) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, mostly non-recirculating, which reduces window of opportunity examine these in blood as they move lung parenchyma. Here, we identify circulating virus-specific cell responses during acute infection with functional, migratory apoptotic patterns modulated by viral proteins associated clinical outcome. Disease severity is predominantly IFN? IL-4 responses, increased against S peptides apoptosis, whereas non-hospitalized patients have IL-12p70 levels, degranulation response N SARS-CoV-2-specific CCR7 + secreting IL-10. In convalescent patients, lung-T frequently detected even 10 months after initial infection, contemporaneous does not reflect tissue-resident profiles. Our study highlights a balanced anti-inflammatory antiviral better outcome persisting important for future protection infection.